![]() ![]() ( 5– 7)īecause SCID is rare and affected infants appear healthy at birth, and the majority of cases have no recognized positive family history, population-based newborn screening was turned to as a strategy to identify infants with SCID sufficiently early in life to provide treatment before the onset of infectious complications. ( 1, 2, 4– 7) Best outcomes are achieved if infants are treated early to avoid infectious complications, as documented by single center reports ( 8) and by retrospective and prospective multicenter studies from the Immune Deficiency Foundation ( 9) and Primary Immune Deficiency Treatment Consortium (PIDTC). In addition, enzyme replacement therapy (ERT) is available for adenosine deaminase (ADA) deficient SCID, and autologous hematopoietic cell correction by gene therapy (GT) has been successful for ADA deficient and X-linked SCID, with Artemis-deficient SCID also being tested in a clinical trial. Haplo-identical parental bone marrow or mobilized peripheral blood hematopoietic stem cells (PBSC) depleted of T cells have been used, ( 4) as well as closely matched bone marrow, PBSCs or cord blood from unrelated donors. ( 3) Advances in allogeneic hematopoietic cell transplantation (HCT) have been pioneered in SCID since that time, with effective treatment, at least with restoration of T cell numbers and function, accomplished by HCT from not only matched siblings, but also from alternative donors. ( 1, 2) SCID was uniformly fatal in the first year of life prior to 1968, when the first successful treatment was reported in a male infant who received a transplant of bone marrow from his healthy, HLA-matched sibling. Individuals affected with SCID have absent or very low numbers of T cells and absent or nonfunctional B cells, rendering them susceptible to life-threatening bacterial, fungal and viral infections with both ordinary and opportunistic pathogens. Severe combined immunodeficiency (SCID) is the term used to describe at least 20 known, and additional unknown, rare genetic disorders in which both T and B cell immunity, the components of the adaptive immune system, are lacking. Previously unknown immune defects have been discovered, as well as conditions not formerly recognized to have low T cells in the neonatal period. Experience has accumulated regarding the range and limitations of diagnoses of newborns with low TRECs and low T cells. ![]() In addition to bringing to attention infants with the primary screening target diseases, typical SCID and leaky SCID (due to hypomorphic mutations in known SCID genes), the newborn screening assay for insufficient TRECs in dried blood spots also reveals infants with non-SCID T lymphopenic conditions. It has proven effective, with infants having this otherwise inapparent but serious, rare disorder achieving survival and immune reconstitution. SCID screening is now the accepted standard of care in state public health departments across the USA, and it is being adopted in many countries. Upon being flagged by an abnormal screening test in a SCID screening program, an infant can receive further diagnostic testing for SCID in the neonatal period, prior to onset of infectious complications, to pemit immediate institution of protective measures and definitive, life-saving treatment to establish a functional immune system. The development of a T cell receptor excision circle (TREC) assay utilizing dried blood spots made possible universal newborn screening (NBS) for severe combined immunodeficiency (SCID) as a public health measure. ![]()
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![]() ![]() When hiking or picnicking, please be a wise visitor and clean up all food and trash - marmots are all over Mount Evans and these giant ground squirrels may try to ask you for some of your food. Other activities on the Mount Evans Highway include cycling, wildlife viewing, stopping at Interpretive Areas and picnicking. You can find information on prices, road closures and conditions here. ![]() There is a small fee to use one of the day-use park areas along the road, but there is no fee just to drive the highway. Idaho Springs is about 33 miles from Denver, making this a simple last-minute day trip. The drive begins in Idaho Springs and is easy to find. In 28 miles, this epic scenic byway climbs 7,000 feet. Want to drive up the highest paved road in all of North America? Mount Evans Scenic Byway gradually takes drivers up through several climate zones and brings you just below the 14,264-foot summit of one of Colorado’s favorite 14ers. ![]() Whether you are looking to drive on North America’s highest paved road, hike Mount Evans Wilderness Area’s trails or enjoy a scenic picnic, you will not be disappointed. Mount Evansĭenver’s closest 14er lies only 40 minutes away in Idaho Springs. Related Read: 7 Scenic Weekend Road Trips from Denver 1. With some amazing Colorado attractions within a couple hours of the city we’ve put together an adventure-packed list of seven of our favorite day trips from Denver. While the Mile High City itself has a lot to offer its residents, its central location makes it easy to get the most out of the Rocky Mountain West. Not only is this state full of breathtaking landscapes and wildlife, it’s also home to 26 scenic byways! Out of those, 11 are designated as America’s Byways making Colorado the most nationally recognized in the country. While many instantly think of mountainous landscapes when they think of Colorado, there is everything from high desert plains to isolated alpine lakes - you’ll find plateaus, sand dunes, sandstone spires, and flatirons too.Īs far as enjoying Colorado’s great outdoors, the state has four beautiful National Parks, 41 worthy-of-exploring State Parks and eight historic National Monuments on 8.3 million acres of public land. Coloradans thrive on getting outdoors, taking scenic drives and strolling through music venue, brewery-filled downtowns. ![]() ![]() Under the "Local User" area, right click "Library" and then select "New Folder." Double click on the new folder to re-name it "Commercial Use" If you'd like to create sub-folders, repeat he same process only right clicking on the "Commercial Use" folder to create a "New Folder" within in.1 bullet journal Level 10 Life printable wheel / circle, with 3 goal info pages included for free! Use these bujo printable Level 10 Life templates to easily achieve your goals and live your best life! This printable product includes three bonus goal info pages- prefilled, blank, and details. ![]() This will open the Silhouette Studio Library. Open Silhouette Studio and click "Library" from the top right menu bar. To organize your commercial use design files in Silhouette Studio, you can do so in the Silhouette Studio Library. Silhouette Studio Library File Organization Repeat this process to create multiple sub-folders. Right click on the folder > Re Name the folder based on how you decide to categorize your designs. To create sub-folders, open the Commercial Use folder you created > Right click > New Folder. If you'd like it in the Documents folder, open the Documents > Right Click > Add Folder. To create a commercial use folder on a MAC open the Finder Panel and decide where you'd like the folder to be stored. Simply call the folder “Commercial Use” and then create sub folders inside the main folder to organize the designs in any way you’d like - by theme, occasion, material, or designer. The easiest way to keep commercial use designs separate from those designs that are for personal use only is to create special folders for them on your computer and/or in your Silhouette Studio library. ![]() ![]() ![]() Vector Art (T Shirts, Stickers, Transfers) ![]() ![]() International customers will be required to pay for returns postage. In addition, UK returns will be supplied a Freepost address to send the item back free of charge. We offer a 100 day no-hassle, returns policy from the purchase date. We charge orders in British Pounds, US dollars or Euros depending on your location. Please be away that pre-order dates occassionally can change due to manufacturing delays. The date is listed next to the 'Add to Cart' button and at the top of the listing description. Look on the listing page for the shipping date of a preorder product. Please note, supplier dates can change check the product listing for the most up to date information. When the item arrives in stock, your preorder will ship and you will receive a shipping notification. When you place a preorder, your payment will be taken immediately and you will receive email confirmation of your order. Please check with your local authorities for more information. If you are outside the UK/USA you may have to pay customs/duties if your country charges for importing packages. Within the UK and USA the price you see is the price you pay - you won't be charged any extra fees. Will I be charged any shipping, customs or duties fees? Do I get a tracking number with my order?Ĭurrently, all orders ship without a tracking number, but we will soon be offering the ability to upgrade to a tracked delivery service. How much does shipping cost?įor most countries including the US and UK, shipping is free. Non-UK orders ship by Royal Mail International Airmail, which usually takes 10-15 working days after despatch, but may take up to 30 days if the item is held by your country's customs officers.ĭeliveries can take longer to arrive at busy periods, such as Christmas, or during emergency situations such as the coronavirus pandemic. UK orders ship by Royal Mail, which should arrive in two to five working days after despatch (but occasionally can take longer). It can take a little longer at busy times, like the Christmas period. If you order an in stock item by 1pm (UK time), your order will ship the same day from Monday to Friday. You can find out more on our About Us page. It's also full of real, live, (friendly!) humans. THE LORD OF THE RINGS: THE FELLOWSHIP OF THE RING and the names of the characters, items, events and places therein are ™ of The Saul Zaentz Company d/b/a Middle-earth Enterprises under license to New Line Productions, Inc.Yes! Merchoid is an award-winning company with seven years' internet retail experience. If you purchase the ULTIMATE THE LORD OF THE RINGS Virtual Challenges Bundle of 8, you will receive 5 THE LORD OF THE RINGS Virtual Challenges entry codes and 3 The Return of the King Virtual Challenges entry codes. The same is applicable for The Return of the King Virtual Challenges. For example, if you purchase THE LORD OF THE RINGS Virtual Challenges Bundle of 5 challenges, the entry codes e-mailed to you will only be eligible to unlock this specific journey. ![]() Thus, the join entry codes will be different. THE LORD OF THE RINGS Virtual Challenges Series and The Return of the King Virtual Challenges Series follow two separate journeys. ![]() Once you have logged in, you'll click "ENTER JOIN CODE" and enter the join code that was emailed to you when you purchased. You will be asked to create an account on the App. The best way to enjoy our Conqueror Challenges is through our mobile app "The Conqueror Challenges" which can be downloaded through the App Store or Google Play. ![]() ![]() ![]() Collected broken toys are broken down, turned into new consumer goods or donated to charity. Attach the free shipping label to the box and drop it off at any UPS location nationally. All pieces fit inside the house, so clean-up and storage is a breeze. Fill an old box with up to ten pounds of broken toys. The fully open back and multiple balconies on the house make arranging and re-arranging all the accessories easy and fun, and encourage cooperative, interactive play. ![]() ![]() They recycle plastic milk bottles and turn them into colourful, child-safe products Free UK delivery over 35. The House Playset features moveable stairs that can be placed anywhere along the second level, from the back of the house to the balconies, and the bathtub, bed, table and chairs can be set up in any room. Green Toys make fun and eco-friendly toys. It’s a dated number and hard to corroborate, but having spent a decent. You can donate plastic jugs toward a great cause If your used commercial playground equipment is made of HDPE plastic, you can recycle that too Remember that. It’s also packaged in recycled and recyclable materials with no plastic films or twist ties, and printed with soy ink. Our safe, commercial-grade outdoor playsets are backed by top-notch customer service. Some 90 of toys are made from plastic, according to an oft-cited 2011 estimate from a European plastics trade publication. With no external coatings, paints, or dyes, this super-safe, durable toy is good for the earth and safe and fun for little ones. Check it out How We Make 100 Recycled Toys We obsess about quality and safety so you don’t have to. We transformed recycled milk jugs into imaginative playthings! Manufactured and assembled in the USA, it’s made from 100% post-consumer recycled plastic milk jugs (HDPE #2 plastic) that save energy and reduce greenhouse gas emissions. Made safe in the USA with 100% recycled materials Rise and Shine! It’s another imagination-filled day at the Green Toys House! This playset features an expansive, multi-leveled house, bright yellow convertible, two mouse characters, staircase, bed, bathtub, table, and two chairs for endless creative play. ![]() ![]() ![]() ![]() The generated activation code copy is activated by clicking in the past, showing that the activation is successful and then can be directly connected to the Internet. Nvmo37DJBZpush481dH2B8oj2sqcXy4ZzpO3DqmIDytUCX Z w2O7jgcK7wHWxHQ Q3bqA63a0cbJPu4yh/RQsjKKbGUk2Qp28MdFrUkaVqRMC7OTosBrffJCtPEzY Ez JJGtWks2Y6 Kr圆IAmFMncoS/fSO1kg3gEoyKTz9EfmEkpJQh0cyBEnz6 aTr3LMġkICB9tjmRrxJUT235JfILtYpeMLfr1agGoMDkByIVGSd8buYAvBENuLCsNlp8Ag XdnC2hais760SZPXa4FU1DwjDFB1IcizYOtihJtnUXudDQcVf1vX eS8XyiWgXad MVidwoai0OrAa/JtlD069n/8GgkidM07vz2h2ExSxw5pswEFXnExAC Cr/EH6ZdHiYglNvr2qnny ZCA3yqkMrB4vnBwmuZJJWeDi ifFzGgu61LvCIt***h9bDartpaRksqRzJKgmTX53zqrNm2lSlog LqYZAIfmA2kfsQ3eSNfFgzexpoDB3SEHf3Jk65nu4pd ZVkRqfn11Q6BFULXu1ZDs7IkM9UgbPN9 YgiN/vrQPaQ/YXQBJ5cKd3o0sG YVUq7OZlGviL61a82bB5MNNNHmSI8Z9tsZTbw3/F2S12C6 r0 Input request code (in Base64), empty line to return: # Copy the request code to the following Then paste the request code to the CMD Window, return to generate activation code ![]() This will prompt you to activate manually. Input request code (in Base64), empty line to return: # To do this, execute the following activation of Navicat Premium software 3.3 activationįirst, disconnect the network and open Navicat Premium.įill in the serial number in the registration interface (this time: NAVM-R5IH-6DBZ-SS5Z), and then activate. SnKey: # Sequence number key (later activated) (input index)>1 # Choose Language (Simplified Chinese) Then execute: navicat-keygen.exe RegPrivateKey.pem C:\navicat-keygen_for_圆4>navicat-keygen.exe RegPrivateKey.pem Then you can see that under the registry folder (C: navicat-keygen_for_圆4), you can have this pem certificate file with the timestamp of the time stamp just executed. This step will take more than a minute, and then the following results will appear: C:\Program Files\PremiumSoft\Navicat Premium 12\libcc.dll has been backed up. C:\navicat-keygen_for_圆4>navicat-patcher.exe "C:\Program Files\PremiumSoft\Navicat Premium 12" To patch the main program of Navicat with navicat-patcher.exe is to replace the public key in it. 3.2 Replacement of Public Key for navicat in CMDįirst, cd goes to the registry directory (my registry directory is C: navicat-keygen_for_圆4), and executes: C:\>cd C:\navicat-keygen_for_圆4 Open source address: (Salute to Open Source)ĭownload packages based on your system, such as navicat-keygen_for_圆4.zipĪfter downloading, decompress (decompressed to the specific directory, default 4 files do not have directories), and place the decompressed registry directory in a location (my registry directory is C: navicat-keygen_for_圆4), recommending to place it on the partition installed by "Navicat Premium". Go to the official website to download the software firstĪfter downloading, the normal installation is completed and the program is not running for the time being. It can be said that it is very convenient. Navicat Premium is similar to a family bucket, which contains a variety of database connections, azure sql, aws, etc. For developers, table building, view building, development model, database synchronization (very commendable), batch tasks, direct generation of ER diagrams, etc. ![]() ![]() ![]() They’re looking to what needs to happen next. I’m thankful that our leaders at the top are looking to the future and aren’t just being complacent and stuck in where we are. They are not getting ready to go out of business. I still have time to do things in the afternoon and in today’s economy, you want to have a job you know is going to be there. The hours, the time we come in, the time we get off. They have full-timers they have part-timers. When I first got here that was what I’m seeking and I’m experiencing it and at this point the sky’s the limit for me. My favorite thing about working at Home Depot is just the opportunity to grow. When I started working here, I thought it was going to be like any other job, where they just like okay you are just another worker, but not here. So from a culture standpoint, we have partners not employees because we want to seek their feedback. They want you to do your job effectively, but they also want you to have fun when you do your job. Lots of trucks coming inbound to unload and then we are loading trucks to go to stores, so there is a lot of forklift traffic. The key word in that title is general, so wherever your business needs you, that’s where we’re going to shift you. The general warehouse associate works in different areas processing inbound and outbound. Our main focus is getting product in front of customers quickly. So if you want to further your career at The Home Depot, this is the place to be.įrom the moment you walk through these doors, you start feeling welcomed. They don’t want you to be stuck at one position. Home Depot is a great company to work for simply because they want you to grow. It is a very energetic place to work and morale is good. I love my fellow peers and my management team. I’ve been in other industries and I would never leave Home Depot, because I love the working environment. ![]() You’re there, first of all, as the face of The Home Depot, because I help them walk out with a smile. We treat our associates with great respect and we have great leadership behind them, so you’ll always be taken care of and it’s a fun working environment. I just generally enjoy being around folks. Oh what makes me good at my job is that I’m a people person. Right now, I’m a cashier part time and I love it, because I love working with the customers. Specific positions may include: Office Associate, Order Fulfillment Associate, Lot Associate, Customer Service Representative, Door Monitor Associate and Associate Coordinator. They must demonstrate a high level of integrity at all times, respond to operational concerns of all associates and remain focused on store specific business objectives while supporting key operational responsibilities. Individuals in these positions must work cooperatively with other Associates, vendors, carriers, and productively with little/some supervision, be detail-oriented, and have proven time management skills. Whether directing customers to store departments or merchandise, answering customer questions on product order status, handling cash management or program compliance, these positions play a critical role in ensuring the highest level of customer satisfaction. Direct customer or vendor interaction is sometimes required for these positions. This may include ensuring an outstanding customer order fulfillment experience, assisting customers in the lot or providing administrative services. Associates in Store Support positions are responsible for a variety of non-sales functions. ![]() ![]() That is, the multiplications are done before the addition.Īnd of course, we encounter the same problems with variables, where it is not feasible to suggest that we do the arithmetic ourself to avoid overflows.įor example, the following overflows, just like its constant equivalent.In order to prevent Integer overflow in your Excel VBA code, you may use the custom Function to perform the Integer to Long type casting like shown below: Sub TestIntegerConversion()įunction myFuncLong(a As Integer, b As Integer) As Long Likewise 60 & + 24*2*6000 overflows even though 60 & is type Long and it appears first, because the subexpression 24*2*6000 is performed as type Integer due to operator precedence. And the data type of any arithmetic operation is determined in a left-to-right evaluation, subject to operator precedence and subexpression parenthesization, not the largest value in the overall expression.įor some details, see the help pages in VBA for "operator precedence", "+ operator", "* operator", etc.įor example, 60 & * 24 * 2 * 6000 works (17280000) because type Long 60 & appears first, so 60 &*24*2 is type Long and the last multiplication is perform as type Long.īut 24 * 2 * 6000 * 60 & overflows because 24*2*6000 is performed as type Integer (largest implicit type so far, left-to-right) and 288000 exceeds type Integer, even though 60 & is type Long. But this is issue is not specific to multiplication. The rest of the calculation is then converted to type Long. Test 6 works because VBA recognizes that the large constant 1234567890 requires type Long. But when that is multiplied by 60, VBA automatically converts bla*24*2 to a the next "larger" type (Long) to fit the result. Likewise for bla*24*2, because 2880 fits in an Integer. Initially, bla=60 results in a Variant subtype Integer. ![]() Test 5 works because variable "bla" is type Variant by default. If you had written LimitTime - (60 * 24) * 2 * 60 without the outer parentheses, you still get an integer overflow because the multiplication has precence, so again the subexpression (60 * 24) * 2 * 60 is evaluated as type Integer. Test 4 fails because, again, the subexpression ((60 * 24) * 2 * 60) is evaluated as type Integer. If you had written CDbl(60) * 24 * 2 * 60 or more simply 60# * 24 * 2 * 60, all arithmetic would have been performed as type Double (overkill). It is not converted to type Double until CDbl processes its parameter. ![]() Test 3 fails because the subexpression 60 * 24 * 2 * 60 is still evaluated as type Integer. The conversion to type Double does not occur until the right-hand value is stored. Test 2 also fails because the type of the right-hand side arithmetic is determined by the types of values on the right-hand side. 'Overflow, although there is a value again the logic seems to transform the multiplication into an integerĭebug.Print 5, Err.Number, Err.Descriptionĭebug.Print 1234567890 - 60 * 24 * blaTwo * 60ĭebug.Print 6, Err.Number, Err.Description 'NO ERROR LimitTime = LimitTime - ((60 * 24) * 2 * 60)ĭebug.Print 4, Err.Number, Err.Description 'Overflow, although forcing a double, also seen as integer ![]() 'Overflow, apparently the Debug.Print can only handle an integer (-32k to +32k)ĭebug.Print 2, Err.Number, Err.Descriptionĭebug.Print 3, Err.Number, Err.Description Debug.Print 1, Err.Number, Err.Description ![]() ![]() Glock 19 Review: What Makes This Gun Stand Out? Image Credit: Original Image from 19FortyFive. If your FFL is not already on file, have them fax a signed copy of their license to 85 and include your name and order number on the cover sheet.Glock 19X. Failure to do so could delay your order processing and shipping. If you do have a dealer selected, please note which FFL will be receiving this item in the Comment box during checkout. If you do not have a dealer in mind we can help you find one in your area. ![]() Discounts will only apply to accessories and parts.įirearm orders generally require 24-48 hours for processing prior to shipping. Please note: No discounts are available on the purchase of Glock factory handguns. If you have any questions, feel free to contact us. All factory parts will still be sent with your Glock purchase. Just add the parts to your shopping cart and please make a note in the comments section providing us with any details or special requests. We can customize and install parts for you at no charge and ship the gun fully assembled and ready to shoot. Gen 4 models are currently unavailable for purchase in California except for certified law enforcement officers.CA/HI/MA/NY models come with two, 10-round magazines.Gen 4 models come with three, 15-round magazines.Gen 3 models come with two, 15-round magazines.For instance, many of the elite pilots of the USAF, Navy SEALS, USMC MARSOC and many others trust the Glock 19 for their efficient defense in emergency situations. In addition to being used as a conventional service weapon, it is suitable for concealed carry or as a backup weapon. With the proven 9x19mm round, it has found worldwide distribution in security services. The Mid-Size or Compact Glock 19 is ideal for concealed carry and everyday shooting because of its reduced dimensions compared with the standard pistol size. Then, you will need to go to that dealer and fulfill the local and state requirements necessary to own a handgun at which time you can take delivery of your Glock. Yes, you can purchase a new Glock handgun on this website and have it shipped to a FFL dealer in your area. If you already own a Glock and want to mill the slide for an optic, we would be honored to assist you. has milled over 4,000 slides for Glock owners nationwide at our new facility in Nashville, TN, and we turn them around in 10 days or less. No waiting, no extra shipping and you save big money. We mill the slide of a new Glock handgun for the Holosun 507K optic and install the optic so it is ready to go. Now you can purchase the GS Optiquipped package at a substantial discount. Looking for something a little more advanced? Want to take shooting Fast and Accurately to the next level… out of the box?! ![]() Please Note: US Made or "US" Models are not available for purchase in California.įirearms must be shipped via Fedex Overnight, to your selected FFL. ![]() Because of this, the Glock 19 is the most popular handgun in the USA. The Glock 19 is known as the most balanced and comfortable sized Glock. The Mid-Size or Compact Glock 19 9mm is ideal for versatile use because of its reduced dimensions compared with the standard pistol size. ![]() ![]() ![]() It seemed absurd,” Simpson writes, “to panic so close to home, but waves of panic were what passed between us, we admitted, when we were safely inside our icy but windless apartment, and could speak again.” In the morning, Delmore calls up to tell them that the temperature had dropped, during their walk, to fourteen below. The ten minute walk up the hill from the subway station takes fifty, the couple feeling the whole time “as though we were wrapped in wet sheets. Poets in Their Youth shows Berryman young and married, trudging back from a dinner party at Delmore and Gertrude Schwartz’s apartment with his wife on a frigid night. Simpson gives us Berryman the young man, and though you can see, by book’s end, the one converge with the other, that doesn’t make her generous portrait any less true. I’ve loved John Berryman-his poetry and his beard-since I was introduced to his work at eighteen, but before reading Poets in Their Youth, I knew only Berryman the mad man. But staring at the figure in black and white induced a kind of vertigo: the yawning gap between Simpson’s Berryman and my Berryman seemed impossibly deep unbridgeable. The caption-“John, Jean, and Cal”-was reassuring. The first time, I did so unthinkingly the second, I flipped through the book itself, to the page where the image originally appears and the figures are identified. Twice, when proofs of our new cover were routing, I was asked to confirm that the cheerful, smiling man to the left of Jean Stafford was indeed John Berryman. Without the trademark beard, the heavy glasses, it’s hard to recognize the depressive poet who would, twenty-six years later, take his own life. The photo on the front of FSG’s reissue of Poets in Their Youth, Eileen Simpson’s memoir of her early marriage to Berryman, shows a younger, lighter man. Each word seems to come from a great distance, to emerge only after a violent struggle. More than drunk, though, he looks pained. ![]() Berryman “was drunk during filming, as the attentive viewer may notice,” runs the quippy description under the video, and sure, he was probably that too. Berryman’s delivery is stilted, almost unnervingly so: his speech is alternately halting and rushed he gestures extravagantly his head bobs and weaves. In so far as there is an image of Berryman that exists in the public imagination, these clips are its embodiment: the poet’s beard is fulsome and his spectacles are large, black, and thickly-framed he is wearing what might be a shoulder-padded overcoat. ![]() |